Motherly loss ends cell cycle

Motherly loss ends cell cycle

T o prevent chromosome segregation errors, cytokinesis in Saccharomyces cerevisiae awaits the arrival of a spindle pole body (SPB) in the bud. On page 335 , Fraschini et al. show that this arrival is announced by the mother-bound SPB, which heralds the onset of cytokinesis and mitotic exit. Mitotic exit relies on a G-protein called Tem1, which activates the destruction of mitotic cyclins. As Te...

Loss of Rb launches cell cycle

The elusive cell cycle– transcription link cientists have known for years that transcription is repressed as cells enter mitosis, yet the mechanistic bridge between the two processes has eluded detection. Now, Jian Chen, Beat Suter (McGill University, Montreal, Canada), and colleagues find that Xpd, a component of the general transcription factor complex, TFIIH, regulates another member of the ...

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Loss of cks1 homeostasis deregulates cell division cycle

Genetic and biochemical studies have provided considerable insight into the multiple functions of cyclin-dependent kinase subunit (cks)1 in cell division cycle. In addition to enhanced substrate targeting by specific ubiquitin ligases SCF(skp2) and APC/C, its direct interaction with proteasome components normalizes multiple cell cycle regulators. Importantly, it also acts as a transcriptional r...

Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants.

Two alleles of the Drosophila melanogaster Rfc4 (DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome cohesion and condensation. These mutations produce larval phenotypes consistent with a role in DNA replication but also result in mitotic chromosomal defects appearing either as premature chromosome condensation-like or pr...